A team from Nagoya University in Japan has identified previously unidentified gene variants that are associated with the development of generalized pustular psoriasis (GPP). The team’s findings, published in the Journal of the American Academy of Dermatology, offer hope for improving diagnosis and therapy. 

GPP is rare, but its effects are often serious. People with GPP can experience recurrent flares of the disease, which include multiple erythematous lesions and sterile pustules over the whole body, often accompanied by fever and chills. This can lead to emergency treatment and even death.

Until now, researchers have reported six genes associated with GPP. Although these genes are widely used for diagnosis and treatment, there remain GPP patients who do not have any variants of these genes. This suggests unknown genetic factors associated with the development of GPP.

To address this problem, a group led by Prof. Masashi Akiyama, Takenori Yoshikawa, and Dr. Takuya Takeichi from the Department of Dermatology at Nagoya University Graduate School of Medicine used next-generation sequencing to investigate the genes of Japanese patients with GPP. They found that higher frequencies of two MEFV gene variants, p.Arg202Gln and p.Ser503Cys, were associated with GPP. In particular, 21% of the patients carried the variant p.Arg202Gln variant and 13% carried the p.Ser503Cys variant.

Pyrin, the product of MEFV, regulates inflammatory pathways. But specific variants of pyrin induce excessive neutrophil migration to tissues, eventually triggering excessive inflammation. This finding, therefore, suggests a likely path for the disease.

The researchers believe that therapies targeting inflammatory pathways related to MEFV are a promising therapeutic strategy for patients with these variants. According to Yoshikawa, their findings suggest a new use for a commonly used drug to treat familial Mediterranean fever (FMF): “As these variants are associated with both FMF and GPP, treatments for FMF may also be effective for the treatment of patients with MEFV-associated GPP.” 

The study, “MEFV variants are a predisposing factor for generalized pustular psoriasis,” was published in the Journal of the American Academy of Dermatology on December 19, 2023, at DOI: 10.1016/j.jaad.2023.10.070.

Authors:

Takenori Yoshikawa, Takuya Takeichi, Kazuki Nishida, Yumiko Kobayashi, Hozumi Sano, Akitaka Shibata, Haruka Koizumi, Reiko Tsutsumi, Ryo Fukaura, Masahiro Hayashi, Akiko Imanishi, Kenta Nakamura, Yasutomo Mikoshiba, Eisaku Ogawa, Shinya Sano, Manao Kinoshita, Takashi Okamoto, Reiko Kageyama, Yuko Sano, Sakae Kaneko, Jun Aoi, Toshihide Hara, Yaei Togawa, Mari Kishibe, Yuichi Yoshida, Hiroaki Yagi, Tetsuya Honda, Kazumitsu Sugiura, Shigetoshi Sano, Tamio Suzuki, Tomoo Ogi, Yoshinao Muro, and Masashi Akiyama

Media Contact:

Matthew Coslett

International Communications Office, Nagoya University

Email: icomm_research@t.mail.nagoya-u.ac.jp

Top image: Higher frequencies of two gene variants were associated with a severe skin disease called Generalized pustular psoriasis (GPP) (credit: Reiko Matsushita)